The show will now be jointly promoted by Frank Warren and Stephen Vaughan Jnr, resulting with the card being televised live and exclusive on BoxNation (Sky Ch. 456, Virgin Ch. 546).
Derry, the former WBU featherweight champion, was last in action in October when he challenged European lightweight champion Gavin Rees for his title, but the contest was ruled a technical draw after four rounds when a clash of heads left Mathews with a badly broken nose.
The 28-year-old had a good run this year before Rees, winning the IBO International title against Scott Lawton; the English title with a first round stoppage of Amir Unsworth and halting Stephen Jennings in the sixth round to claim the British Masters title.
Lazio born Marsili, ranked ninth in Europe, is the current Italian champion and is unbeaten in 24 fights, but this will be his first fight outside of his country.
"It's great to be the main event in my home city for this title opportunity and I'm going to win it in front of my fans," says Derry. "The fight will be live on the new UK fight channel BoxNation that has already televised some great fights this and I'm looking to put on a good show for the viewers against Marsili.
"I'm not expecting an easy night, he's unbeaten, he's away from home so all the pressure will be on me to perform, but I'll rise to the occasion."
Vaughan said: "It's set to be a cracking show featuring some of Liverpool's best up-and-coming talent and headlined by Liverpool's favourite son Derry Matthews. He's got a tough fight on his hands, but we've worked hard to get Marsili over here and now it's down to Derry to win the title on his patch."
Frank Warren added: "Mathews v Marsili is another good fight added to January's schedule that also features the British Cruiserweight title between Leon Williams and Tony Conquest with more fights to be announced."
Tickets are on sale now from the Olmpia box office on 0151 263 6633.
